Altered Expression of Zonula occludens-1 Affects Cardiac Na<sup>+</sup> Channels and Increases Susceptibility to Ventricular Arrhythmias

Altered Expression of Zonula occludens-1 Affects Cardiac Na<sup>+</sup> Channels and Increases Susceptibility to Ventricular Arrhythmias

Zonula occludens-1 (ZO-1) is an intracellular scaffolding protein that orchestrates the anchoring of membrane proteins to the cytoskeleton in epithelial and specialized tissue including the heart. There is clear evidence to support the central role of intracellular auxiliary proteins in arrhythmogen...

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Bibliographic Details
Main Authors: Mona El Refaey, Sara Coles, Hassan Musa, Tyler L. Stevens, Michael J. Wallace, Nathaniel P. Murphy, Steve Antwi-Boasiako, Lindsay J. Young, Heather R. Manring, Jerry Curran, Michael A. Makara, Kelli Sas, Mei Han, Sara N. Koenig, Michel Skaf, Crystal F. Kline, Paul M. L. Janssen, Federica Accornero, Maegen A. Borzok, Peter J. Mohler
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Cells
Subjects:
heart failure
gap junction
sodium channel (Na<sub>V</sub>1.5)
connexin-43
Zonula occludens-1 (ZO-1)
late sodium current
Online Access:https://www.mdpi.com/2073-4409/11/4/665

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https://www.mdpi.com/2073-4409/11/4/665

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