Regulation of the Intestinal Extra-Adrenal Steroidogenic Pathway Component LRH-1 by Glucocorticoids in Ulcerative Colitis

Regulation of the Intestinal Extra-Adrenal Steroidogenic Pathway Component LRH-1 by Glucocorticoids in Ulcerative Colitis

Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) and can be treated with glucocorticoids (GC), although some patients are unresponsive to this therapy. The transcription factor LRH-1/<i>NR5A2</i> is critical to intestinal cortisol production (intestinal steroidogenesis), be...

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Bibliographic Details
Main Authors: Glauben Landskron, Karen Dubois-Camacho, Octavio Orellana-Serradell, Marjorie De la Fuente, Daniela Parada-Venegas, Mirit Bitrán, David Diaz-Jimenez, Shuang Tang, John A. Cidlowski, Xiaoling Li, Hector Molina, Carlos M. Gonzalez, Daniela Simian, Jaime Lubascher, Victor Pola, Martín Montecino, Tjasso Blokzijl, Klaas Nico Faber, María-Julieta González, Rodrigo Quera, Marcela A. Hermoso
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Cells
Subjects:
LRH-1
glucocorticoid receptor
ulcerative colitis
steroid refractoriness
steroid dependency
Online Access:https://www.mdpi.com/2073-4409/11/12/1905

Internet

https://www.mdpi.com/2073-4409/11/12/1905

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