MR Tractography-Based Targeting and Physiological Identification of the Cuneiform Nucleus for Directional DBS in a Parkinson’s Disease Patient With Levodopa-Resistant Freezing of Gait

MR Tractography-Based Targeting and Physiological Identification of the Cuneiform Nucleus for Directional DBS in a Parkinson’s Disease Patient With Levodopa-Resistant Freezing of Gait

BackgroundFreezing of gait (FOG) is a debilitating motor deficit in a subset of Parkinson’s Disease (PD) patients that is poorly responsive to levodopa or deep brain stimulation (DBS) of established PD targets. The proposal of a DBS target in the midbrain, known as the pedunculopontine nucleus (PPN)...

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Bibliographic Details
Main Authors: Stephano J. Chang, Iahn Cajigas, James D. Guest, Brian R. Noga, Eva Widerström-Noga, Ihtsham Haq, Letitia Fisher, Corneliu C. Luca, Jonathan R. Jagid
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Human Neuroscience
Subjects:
freezing of gait
gait dysfunction
Parkinson’s Disease
mesencephalic locomotor region
cuneiform nucleus
pedunculopontine nucleus
Online Access:https://www.frontiersin.org/articles/10.3389/fnhum.2021.676755/full

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https://www.frontiersin.org/articles/10.3389/fnhum.2021.676755/full

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