Molecular Disorder of Bicalutamide—Amorphous Solid Dispersions Obtained by Solvent Methods

Molecular Disorder of Bicalutamide—Amorphous Solid Dispersions Obtained by Solvent Methods

The effect of solvent removal techniques on phase transition, physical stability and dissolution of bicalutamide from solid dispersions containing polyvinylpyrrolidone (PVP) as a carrier was investigated. A spray dryer and a rotavapor were applied to obtain binary systems containing either 50% or 66...

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Bibliographic Details
Main Authors: Joanna Szafraniec, Agata Antosik, Justyna Knapik-Kowalczuk, Karolina Gawlak, Mateusz Kurek, Jakub Szlęk, Witold Jamróz, Marian Paluch, Renata Jachowicz
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:Pharmaceutics
Subjects:
bicalutamide
PVP
solid dispersion
spray drying
evaporation
dissolution
amorphization
Online Access:http://www.mdpi.com/1999-4923/10/4/194

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http://www.mdpi.com/1999-4923/10/4/194

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