Synergy of nanodiamond–doxorubicin conjugates and PD-L1 blockade effectively turns tumor-associated macrophages against tumor cells

Synergy of nanodiamond–doxorubicin conjugates and PD-L1 blockade effectively turns tumor-associated macrophages against tumor cells

Abstract Background Tumor-associated macrophages (TAMs) are the most abundant stromal cells in the tumor microenvironment. Turning the TAMs against their host tumor cells is an intriguing therapeutic strategy particularly attractive for patients with immunologically “cold” tumors. This concept was m...

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Bibliographic Details
Main Authors: Hua-Zhen Xu, Tong-Fei Li, Chao Wang, Yan Ma, Yan Liu, Mei-Yan Zheng, Zhang-Jun-Yan Liu, Jin-Bo Chen, Ke Li, Shi-Kuan Sun, Naoki Komatsu, Yong-Hong Xu, Li Zhao, Xiao Chen
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Journal of Nanobiotechnology
Subjects:
PD-L1/PD-1
Non-small cell lung cancer
Tumor-associated macrophages
HMGB1/RAGE/NF-κB signaling
Nanodiamond–doxorubicin conjugates
Online Access:https://doi.org/10.1186/s12951-021-01017-w

Internet

https://doi.org/10.1186/s12951-021-01017-w

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