Smith–Magenis syndrome protein RAI1 regulates body weight homeostasis through hypothalamic BDNF-producing neurons and neurotrophin downstream signalling

Smith–Magenis syndrome protein RAI1 regulates body weight homeostasis through hypothalamic BDNF-producing neurons and neurotrophin downstream signalling

Retinoic acid-induced 1 (RAI1) haploinsufficiency causes Smith–Magenis syndrome (SMS), a genetic disorder with symptoms including hyperphagia, hyperlipidemia, severe obesity, and autism phenotypes. RAI1 is a transcriptional regulator with a pan-neural expression pattern and hundreds of downstream ta...

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Bibliographic Details
Main Authors: Sehrish Javed, Ya-Ting Chang, Yoobin Cho, Yu-Ju Lee, Hao-Cheng Chang, Minza Haque, Yu Cheng Lin, Wei-Hsiang Huang
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-11-01
Series:eLife
Subjects:
obesity
retinoic acid induced 1
brain-derived neurotrophic factor
paraventricular nucleus of hypothalamus
Online Access:https://elifesciences.org/articles/90333

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https://elifesciences.org/articles/90333

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