Avermectin induces carp neurotoxicity by mediating blood-brain barrier dysfunction, oxidative stress, inflammation, and apoptosis through PI3K/Akt and NF-κB pathways

Avermectin induces carp neurotoxicity by mediating blood-brain barrier dysfunction, oxidative stress, inflammation, and apoptosis through PI3K/Akt and NF-κB pathways

Avermectin, a ''low toxicity insecticide'', has been widely used in recent years, but its non-target toxicity, especially to aquatic organisms, has been neglected. In this study, we evaluated the neurotoxic effects of avermectin on carp by establishing a 96 h avermectin acute tox...

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Bibliographic Details
Main Authors: Tianmeng Zhang, Zhuhua Dong, Feixue Liu, Enzhuang Pan, Nana He, Fenfen Ma, Guanglu Wang, Yan Wang, Jingquan Dong
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Avermectin
Neurotoxicity
Carp
NF-κB
PI3K/Akt
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651322008016

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http://www.sciencedirect.com/science/article/pii/S0147651322008016

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