Homeodomain-only protein suppresses proliferation and contributes to differentiation- and age-related reduced CD8+ T cell expansion

T cell activation is a tightly controlled process involving both positive and negative regulators. The precise mechanisms governing the negative regulators in T cell proliferation remain incompletely understood. Here, we report that homeodomain-only protein (HOPX), a homeodomain-containing protein,...

Full description

Bibliographic Details
Main Authors: Qian Yang, Michael Patrick, Jian Lu, Joseph Chen, Yongqing Zhang, Humza Hemani, Elin Lehrmann, Supriyo De, Nan-ping Weng
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Immunology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1360229/full