Using the canine microbiome to bridge translation of cancer immunotherapy from pre-clinical murine models to human clinical trials

Using the canine microbiome to bridge translation of cancer immunotherapy from pre-clinical murine models to human clinical trials

The microbiome has clearly been established as a cutting-edge field in tumor immunology and immunotherapy. Growing evidence supports the role of the microbiome in immune surveillance, self-tolerance, and response to immune checkpoint inhibitors such as anti PD-L1 and CTLA-4 blockade (1–6). Moreover,...

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Bibliographic Details
Main Authors: Kara T. Kleber, Khurshid R. Iranpur, Lauren M. Perry, Sylvia M. Cruz, Aryana M. Razmara, William T. N. Culp, Michael S. Kent, Jonathan A. Eisen, Robert B. Rebhun, Robert J. Canter
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Immunology
Subjects:
microbiome
immunotherapy
cancer
comparative oncology
canines
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.983344/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.983344/full

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