TRAF6 Suppresses the Development of Pulmonary Fibrosis by Attenuating the Activation of Fibroblasts

TRAF6 Suppresses the Development of Pulmonary Fibrosis by Attenuating the Activation of Fibroblasts

Pulmonary fibrosis (PF) has a high mortality rate, and its pathogenesis is unknown. TNF receptor-associated factor 6 (TRAF6), a signal transducer for inflammatory signaling, plays crucial roles in the pathogenesis of immune diseases. However, its function in PF remains unknown. Herein, we demonstrat...

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Bibliographic Details
Main Authors: Jiali Min, Qiao Li, Suosi Liu, Qianrong Wang, Min Yin, Yan Zhang, Jun Yan, Bing Cui, Shanshan Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Pharmacology
Subjects:
pulmonary fibrosis
TRAF6
lung fibroblast
TRIB3
ubiquitination
protein degradation
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.911945/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.911945/full

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