MALT1 auto-proteolysis is essential for NF-κB-dependent gene transcription in activated lymphocytes.

MALT1 auto-proteolysis is essential for NF-κB-dependent gene transcription in activated lymphocytes.

Mucosa-associated lymphoid tissue 1 (MALT1) controls antigen receptor-mediated signalling to nuclear factor κB (NF-κB) through both its adaptor and protease function. Upon antigen stimulation, MALT1 forms a complex with BCL10 and CARMA1, which is essential for initial IκBα phosphorylation and NF-κB...

Full description

Bibliographic Details
Main Authors: Mathijs Baens, Luca Bonsignore, Riet Somers, Charlotte Vanderheydt, Stephen D Weeks, Jenny Gunnarsson, Ewa Nilsson, Robert G Roth, Margot Thome, Peter Marynen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0103774&type=printable

Internet

https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0103774&type=printable

Similar Items