Diluted Fecal Community Transplant Restores Clostridioides difficile Colonization Resistance to Antibiotic-Perturbed Murine Communities

Diluted Fecal Community Transplant Restores Clostridioides difficile Colonization Resistance to Antibiotic-Perturbed Murine Communities

ABSTRACT Fecal communities transplanted into individuals can eliminate recurrent Clostridioides difficile infection (CDI) with high efficacy. However, this treatment is only used once CDI becomes resistant to antibiotics or has recurred multiple times. We sought to investigate whether a fecal commun...

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Bibliographic Details
Main Authors: Nicholas A. Lesniak, Sarah Tomkovich, Andrew Henry, Ana Taylor, Joanna Colovas, Lucas Bishop, Kathryn McBride, Patrick D. Schloss
Format: Article
Language:English
Published: American Society for Microbiology 2022-08-01
Series:mBio
Subjects:
Clostridioides difficile
colonization resistance
microbial ecology
microbiome
fecal transplant
mice
Online Access:https://journals.asm.org/doi/10.1128/mbio.01364-22

Internet

https://journals.asm.org/doi/10.1128/mbio.01364-22

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