IRF1 governs the expression of SMARCC1 via the GCN5-SETD2 axis and actively engages in the advancement of osteoarthritis

IRF1 governs the expression of SMARCC1 via the GCN5-SETD2 axis and actively engages in the advancement of osteoarthritis

Background: Osteoarthritis (OA) is a degenerative joint disease characterized by the breakdown of joint cartilage and underlying bone. Macrophages are a type of white blood cell that plays a critical role in the immune system and can be found in various tissues, including joints. Research on the rel...

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Bibliographic Details
Main Authors: Dong Wang, Yujun Zhang, Liangping Zhang, Du He, Lan Zhao, Zhimin Miao, Wei Cheng, Chengyue Zhu, Li Zhu, Wei Zhang, Hongting Jin, Hang Zhu, Hao Pan
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Journal of Orthopaedic Translation
Subjects:
Epigenetics
GCN5
IRF1-SMARCC1 axis
Macrophages
Osteoarthritis
SETD2
Online Access:http://www.sciencedirect.com/science/article/pii/S2214031X24000044

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http://www.sciencedirect.com/science/article/pii/S2214031X24000044

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