Sulfonylpiperazine compounds prevent Plasmodium falciparum invasion of red blood cells through interference with actin-1/profilin dynamics.

Sulfonylpiperazine compounds prevent Plasmodium falciparum invasion of red blood cells through interference with actin-1/profilin dynamics.

With emerging resistance to frontline treatments, it is vital that new antimalarial drugs are identified to target Plasmodium falciparum. We have recently described a compound, MMV020291, as a specific inhibitor of red blood cell (RBC) invasion, and have generated analogues with improved potency. He...

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Bibliographic Details
Main Authors: Madeline G Dans, Henni Piirainen, William Nguyen, Sachin Khurana, Somya Mehra, Zahra Razook, Niall D Geoghegan, Aurelie T Dawson, Sujaan Das, Molly Parkyn Schneider, Thorey K Jonsdottir, Mikha Gabriela, Maria R Gancheva, Christopher J Tonkin, Vanessa Mollard, Christopher Dean Goodman, Geoffrey I McFadden, Danny W Wilson, Kelly L Rogers, Alyssa E Barry, Brendan S Crabb, Tania F de Koning-Ward, Brad E Sleebs, Inari Kursula, Paul R Gilson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-04-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3002066

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https://doi.org/10.1371/journal.pbio.3002066

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