Activation of PI3K/AKT/mTOR signaling axis by UBE2S inhibits autophagy leading to cisplatin resistance in ovarian cancer

Activation of PI3K/AKT/mTOR signaling axis by UBE2S inhibits autophagy leading to cisplatin resistance in ovarian cancer

Abstract Background Epithelial ovarian cancer (OC) is the fourth leading cause of cancer-related deaths in women, with a 5-year survival rate of 30%-50%. Platinum resistance is the chief culprit for the high recurrence and mortality rates. Several studies confirm that the metabolic regulation of ubi...

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Bibliographic Details
Main Authors: Mengjun Zhang, Jialin Wang, Yan Guo, Haodi Yue, Lindong Zhang
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Journal of Ovarian Research
Subjects:
Epithelial OC
Platinum resistance
Ubiquitin-conjugating enzyme E2S
Autophagy
Online Access:https://doi.org/10.1186/s13048-023-01314-y

Internet

https://doi.org/10.1186/s13048-023-01314-y

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