Phenformin Down-Regulates c-Myc Expression to Suppress the Expression of Pro-Inflammatory Cytokines in Keratinocytes

Phenformin Down-Regulates c-Myc Expression to Suppress the Expression of Pro-Inflammatory Cytokines in Keratinocytes

The treatment of many skin inflammation diseases, such as psoriasis and atopic dermatitis, is still a challenge and inflammation plays important roles in multiple stages of skin tumor development, including initiation, promotion and metastasis. Phenformin, a biguanide drug, has been shown to play a...

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Bibliographic Details
Main Authors: Guanyi Liu, Dingyang Li, Liwei Zhang, Qiuping Xu, Dexuan Zhuang, Panpan Liu, Ling Hu, Huiting Deng, Jianfeng Sun, Shuangshuang Wang, Bin Zheng, Jing Guo, Xunwei Wu
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Cells
Subjects:
skin inflammation
phenformin
cytokines
c-Myc
mTOR
Online Access:https://www.mdpi.com/2073-4409/11/15/2429

Internet

https://www.mdpi.com/2073-4409/11/15/2429

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