Experimental dopaminergic neuron lesion at the area of the biological clock pacemaker, suprachiasmatic nuclei (SCN) induces metabolic syndrome in rats

Abstract Background The daily peak in dopaminergic neuronal activity at the area of the biological clock (hypothalamic suprachiasmatic nuclei [SCN]) is diminished in obese/insulin resistant vs lean/insulin sensitive animals. The impact of targeted lesioning of dopamine (DA) neurons specifically at t...

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Bibliographic Details
Main Authors: Shuqin Luo, Michael Ezrokhi, Nicholas Cominos, Tsung-Huang Tsai, Carl R. Stoelzel, Yelena Trubitsyna, Anthony H. Cincotta
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Diabetology & Metabolic Syndrome
Subjects:
Online Access:https://doi.org/10.1186/s13098-021-00630-x