Pharmacogenetic Approaches to Enhancing Efficacy and Safety of Statins as Illustrated by the Example of Atorvastatin

Pharmacogenetic Approaches to Enhancing Efficacy and Safety of Statins as Illustrated by the Example of Atorvastatin

Statins are efficacious lipid-lowering drugs used for prevention of cardiovascular complications in patients with high blood cholesterol. The efficacy and safety of this group of drugs is largely determined by genetic factors. The aim of the study was to analyse the effect of gene polymorphisms on t...

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Bibliographic Details
Main Authors: R. Ye. Kazakov, O. A. Checha, I. A. Mazerkina, E. Yu. Demchenkova, T. A. Aleksandrova, V. A. Evteev, S. A. Belkov, A. B. Prokofiev
Format: Article
Language:Russian
Published: Ministry of Health of the Russian Federation, Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products» 2020-03-01
Series:Безопасность и риск фармакотерапии
Subjects:
pharmacogenetics
genotyping
genetic biomarkers
statins
atorvastatin
single nucleotide polymorphisms
p-glycoprotein
organic anion transporters
slco1b1
abcb1
cyp2c9
cyp2c19
Online Access:https://www.risksafety.ru/jour/article/view/160

Internet

https://www.risksafety.ru/jour/article/view/160

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