TRIM21 restricts influenza A virus replication by ubiquitination-dependent degradation of M1.

TRIM21 restricts influenza A virus replication by ubiquitination-dependent degradation of M1.

Tripartite motif-containing protein 21 (TRIM21), an E3 ubiquitin ligase, plays a critical role in the host antiviral response. However, the mechanism and antiviral spectrum of TRIM21 in influenza A virus (IAV) remain unclear. Here, we report that TRIM21 inhibits the replication of various IAV subtyp...

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Bibliographic Details
Main Authors: Lulu Lin, Xingbo Wang, Zhen Chen, Tingjuan Deng, Yan Yan, Weiren Dong, Yu Huang, Jiyong Zhou
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-06-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1011472

Internet

https://doi.org/10.1371/journal.ppat.1011472

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