TRIM21 restricts influenza A virus replication by ubiquitination-dependent degradation of M1.
Tripartite motif-containing protein 21 (TRIM21), an E3 ubiquitin ligase, plays a critical role in the host antiviral response. However, the mechanism and antiviral spectrum of TRIM21 in influenza A virus (IAV) remain unclear. Here, we report that TRIM21 inhibits the replication of various IAV subtyp...
Main Authors: | Lulu Lin, Xingbo Wang, Zhen Chen, Tingjuan Deng, Yan Yan, Weiren Dong, Yu Huang, Jiyong Zhou |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2023-06-01
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Series: | PLoS Pathogens |
Online Access: | https://doi.org/10.1371/journal.ppat.1011472 |
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