Incidence of microvascular dysfunction is increased in hyperlipidemic mice, reducing cerebral blood flow and impairing remote memory

Incidence of microvascular dysfunction is increased in hyperlipidemic mice, reducing cerebral blood flow and impairing remote memory

IntroductionThe development of cognitive dysfunction is not necessarily associated with diet-induced obesity. We hypothesized that cognitive dysfunction might require additional vascular damage, for example, in atherosclerotic mice.MethodsWe induced atherosclerosis in male C57BL/6N mice by injecting...

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Bibliographic Details
Main Authors: Luis Daniel Hernandez Torres, Flavia Rezende, Eva Peschke, Olga Will, Jan-Bernd Hövener, Frauke Spiecker, Ümit Özorhan, Josephine Lampe, Ines Stölting, Zouhair Aherrahrou, Carsten Künne, Kristina Kusche-Vihrog, Urte Matschl, Susanne Hille, Ralf P. Brandes, Markus Schwaninger, Oliver J. Müller, Walter Raasch
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Endocrinology
Subjects:
atherosclerosis AAV-PCSK9DY mouse model
cognitive dysfunction
cerebral blood flow
hyperlipidemia
pericytes
patchy blood-brain barrier leaks
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2024.1338458/full

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https://www.frontiersin.org/articles/10.3389/fendo.2024.1338458/full

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