scIBD: a self-supervised iterative-optimizing model for boosting the detection of heterotypic doublets in single-cell chromatin accessibility data

scIBD: a self-supervised iterative-optimizing model for boosting the detection of heterotypic doublets in single-cell chromatin accessibility data

Abstract Application of the widely used droplet-based microfluidic technologies in single-cell sequencing often yields doublets, introducing bias to downstream analyses. Especially, doublet-detection methods for single-cell chromatin accessibility sequencing (scCAS) data have multiple assay-specific...

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Bibliographic Details
Main Authors: Wenhao Zhang, Rui Jiang, Shengquan Chen, Ying Wang
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Genome Biology
Subjects:
Single-cell
Chromatin accessibility
Doublets
Detection
Online Access:https://doi.org/10.1186/s13059-023-03072-y

Internet

https://doi.org/10.1186/s13059-023-03072-y

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