Discovery of new TLR7 agonists by a combination of statistical learning-based QSAR, virtual screening, and molecular dynamics

Discovery of new TLR7 agonists by a combination of statistical learning-based QSAR, virtual screening, and molecular dynamics

Search for new antiviral medications has surged in the past two years due to the COVID-19 crisis. Toll-like receptor 7 (TLR7) is among one of the most important TLR proteins of innate immunity that is responsible for broad antiviral response and immune system control. TLR7 agonists, as both vaccine...

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Bibliographic Details
Main Authors: Ardavan Abiri, Masoud Rezaei, Mohammad Hossein Zeighami, Younes Vaezpour, Leili Dehghan, Maedeh KhorramGhahfarokhi
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Informatics in Medicine Unlocked
Subjects:
TLR7
Antiviral
Statistical learning
Drug design
QSAR
Molecular docking
Online Access:http://www.sciencedirect.com/science/article/pii/S2352914821002586

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http://www.sciencedirect.com/science/article/pii/S2352914821002586

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