Unraveling the role of HIF and epigenetic regulation in pulmonary arterial hypertension: implications for clinical research and its therapeutic approach

Unraveling the role of HIF and epigenetic regulation in pulmonary arterial hypertension: implications for clinical research and its therapeutic approach

Pulmonary arterial hypertension (PAH) is characterized by pulmonary vascular remodeling with high pulmonary pressure, which ultimately leads to right heart failure and premature death. Emerging evidence suggests that both hypoxia and epigenetics play a pivotal role in the pathogenesis of PAH develop...

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Bibliographic Details
Main Authors: Ankita Mitra, Dan Yi, Zhiyu Dai, Vinicio de Jesus Perez
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-10-01
Series:Frontiers in Medicine
Subjects:
hypoxia inducible factor
epigenetics
pulmonary arterial hypertension
animal model
therapeutics
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2024.1460376/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2024.1460376/full

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