Placental mesenchymal stem cells ameliorate NLRP3 inflammasome-induced ovarian insufficiency by modulating macrophage M2 polarization

Placental mesenchymal stem cells ameliorate NLRP3 inflammasome-induced ovarian insufficiency by modulating macrophage M2 polarization

Abstract Background Premature ovarian insufficiency (POI) is a common clinical problem, however, there are currently no effective therapies. Pyroptosis induced by the NLRP3 inflammasome is considered a possible mechanism of POI. Placental mesenchymal stem cells (PMSCs) have excellent immunomodulator...

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Bibliographic Details
Main Authors: Dongmei Chen, Na Hu, Shasha Xing, Li Yang, Feiyan Zhang, Songlin Guo, Shudan Liu, Xiaona Ma, Xueyun Liang, Huiming Ma
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Journal of Ovarian Research
Subjects:
Placental mesenchymal stem cells
Premature ovarian insufficiency
Macrophage
Inflammasome
NLRP3
Interferon-γ
Online Access:https://doi.org/10.1186/s13048-023-01136-y

Internet

https://doi.org/10.1186/s13048-023-01136-y

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