Contributions of T cell dysfunction to the resistance against anti-PD-1 therapy in oral carcinogenesis

Contributions of T cell dysfunction to the resistance against anti-PD-1 therapy in oral carcinogenesis

Abstract Background Programmed death 1 (PD-1) blockade has great effect in the prevention of oral precancerous lesions, but the drug resistance has also been observed. The determinants of immune resistance during the malignant transformation are poorly understood. Methods Anti-PD-1 antibody was admi...

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Bibliographic Details
Main Authors: Liling Wen, Huanzi Lu, Qiusheng Li, Qunxing Li, Shuqiong Wen, Dikan Wang, Xi Wang, Juan Fang, Jun Cui, Bin Cheng, Zhi Wang
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Oral precancerous lesion (OPL)
Programmed cell death 1(PD-1)
Central memory T cell (Tcm)
Regulatory T cell (Treg)
T cell immunoglobulin and mucin domain-containing protein 3 (TIM-3)
Online Access:http://link.springer.com/article/10.1186/s13046-019-1185-0

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http://link.springer.com/article/10.1186/s13046-019-1185-0

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