The Unfolded Protein Response Sensor PERK Mediates Stiffness-Dependent Adaptation in Glioblastoma Cells

The Unfolded Protein Response Sensor PERK Mediates Stiffness-Dependent Adaptation in Glioblastoma Cells

Glioblastoma multiforme (GBM) is the most aggressive brain tumor in adults. In addition to genetic causes, the tumor microenvironment (TME), including stiffening of the extracellular matrix (ECM), is a main driver of GBM progression. Mechano-transduction and the unfolded protein response (UPR) are e...

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Bibliographic Details
Main Authors: Mohammad Khoonkari, Dong Liang, Marina Trombetta Lima, Tjitze van der Land, Yuanke Liang, Jianwu Sun, Amalia Dolga, Marleen Kamperman, Patrick van Rijn, Frank A. E. Kruyt
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:International Journal of Molecular Sciences
Subjects:
glioblastoma
extracellular matrix stiffening
tumor microenvironment
mechanical stress
PERK
unfolded protein response
Online Access:https://www.mdpi.com/1422-0067/23/12/6520

Internet

https://www.mdpi.com/1422-0067/23/12/6520

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