p14ARF induces the relocation of HDM2 and p53 to extranucleolar sites that are targeted by PML bodies and proteasomes

<p>Abstract</p> <p>Background</p> <p>p14ARF is a protein product of the alternative reading frame of the human INK4a locus. It functions as a tumor suppressor protein. p14ARF suppresses growth through p53-dependent and p53-independent pathways.</p> <p>Result...

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Bibliographic Details
Main Authors: Klein George, Mattsson Karin, Kashuba Elena, Szekely Laszlo
Format: Article
Language:English
Published: BMC 2003-03-01
Series:Molecular Cancer
Online Access:http://www.molecular-cancer.com/content/2/1/18