Differential Targeting of c-Maf, Bach-1, and Elmo-1 by microRNA-143 and microRNA-365 Promotes the Intracellular Growth of Mycobacterium tuberculosis in Alternatively IL-4/IL-13 Activated Macrophages

Differential Targeting of c-Maf, Bach-1, and Elmo-1 by microRNA-143 and microRNA-365 Promotes the Intracellular Growth of Mycobacterium tuberculosis in Alternatively IL-4/IL-13 Activated Macrophages

Mycobacterium tuberculosis (Mtb) can subvert the host defense by skewing macrophage activation toward a less microbicidal alternative activated state to avoid classical effector killing functions. Investigating the molecular basis of this evasion mechanism could uncover potential candidates for host...

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Bibliographic Details
Main Authors: Ousman Tamgue, Lorna Gcanga, Mumin Ozturk, Lauren Whitehead, Shandre Pillay, Raygaana Jacobs, Sugata Roy, Sebastian Schmeier, Malika Davids, Yulia A. Medvedeva, Keertan Dheda, Harukazu Suzuki, Frank Brombacher, Reto Guler
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Immunology
Subjects:
microRNA-143
microRNA-365
alternative activated macrophages
Mycobacterium tuberculosis
CAGE transcriptomics
c-Maf
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00421/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00421/full

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