The impact of hepatocyte-specific deletion of hypoxia-inducible factors on the development of polymicrobial sepsis with focus on GR and PPARα function

The impact of hepatocyte-specific deletion of hypoxia-inducible factors on the development of polymicrobial sepsis with focus on GR and PPARα function

IntroductionPolymicrobial sepsis causes acute anorexia (loss of appetite), leading to lipolysis in white adipose tissue and proteolysis in muscle, and thus release of free fatty acids (FFAs), glycerol and gluconeogenic amino acids. Since hepatic peroxisome proliferator-activated receptor alpha (PPAR...

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Bibliographic Details
Main Authors: Tineke Vanderhaeghen, Steven Timmermans, Melanie Eggermont, Deepika Watts, Jolien Vandewalle, Charlotte Wallaeys, Louise Nuyttens, Joyca De Temmerman, Tino Hochepied, Sylviane Dewaele, Joke Vanden Berghe, Niek Sanders, Ben Wielockx, Rudi Beyaert, Claude Libert
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Immunology
Subjects:
sepsis
hypoxia
detection
metabolism
glucocorticoids (GCs)
PPARalpha
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1124011/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1124011/full

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