The impact of hepatocyte-specific deletion of hypoxia-inducible factors on the development of polymicrobial sepsis with focus on GR and PPARα function
IntroductionPolymicrobial sepsis causes acute anorexia (loss of appetite), leading to lipolysis in white adipose tissue and proteolysis in muscle, and thus release of free fatty acids (FFAs), glycerol and gluconeogenic amino acids. Since hepatic peroxisome proliferator-activated receptor alpha (PPAR...
Main Authors: | Tineke Vanderhaeghen, Steven Timmermans, Melanie Eggermont, Deepika Watts, Jolien Vandewalle, Charlotte Wallaeys, Louise Nuyttens, Joyca De Temmerman, Tino Hochepied, Sylviane Dewaele, Joke Vanden Berghe, Niek Sanders, Ben Wielockx, Rudi Beyaert, Claude Libert |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2023-03-01
|
Series: | Frontiers in Immunology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1124011/full |
Similar Items
-
Turning a pathogen protein into a therapeutic tool for sepsis
by: Tineke Vanderhaeghen, et al.
Published: (2021-01-01) -
Zinc inhibits lethal inflammatory shock by preventing microbe‐induced interferon signature in intestinal epithelium
by: Jolien Souffriau, et al.
Published: (2020-10-01) -
Loss of PPARα function promotes epigenetic dysregulation of lipid homeostasis driving ferroptosis and pyroptosis lipotoxicity in metabolic dysfunction associated Steatotic liver disease (MASLD)
by: Claudia Theys, et al.
Published: (2024-01-01) -
Dimerization of the Glucocorticoid Receptor and Its Importance in (Patho)physiology: A Primer
by: Steven Timmermans, et al.
Published: (2022-02-01) -
Hepatic Peroxisome Proliferator-Activated Receptor Alpha Dysfunction in Porcine Septic Shock
by: Jolien Vandewalle, et al.
Published: (2022-12-01)