Shared genetic architecture between irritable bowel syndrome and psychiatric disorders reveals molecular pathways of the gut-brain axis

Shared genetic architecture between irritable bowel syndrome and psychiatric disorders reveals molecular pathways of the gut-brain axis

Abstract Background Irritable bowel syndrome (IBS) often co-occurs with psychiatric and gastrointestinal disorders. A recent genome-wide association study (GWAS) identified several genetic risk variants for IBS. However, most of the heritability remains unidentified, and the genetic overlap with psy...

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Bibliographic Details
Main Authors: Markos Tesfaye, Piotr Jaholkowski, Guy F. L. Hindley, Alexey A. Shadrin, Zillur Rahman, Shahram Bahrami, Aihua Lin, Børge Holen, Nadine Parker, Weiqiu Cheng, Linn Rødevand, Oleksandr Frei, Srdjan Djurovic, Anders M. Dale, Olav B. Smeland, Kevin S. O’Connell, Ole A. Andreassen
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Genome Medicine
Subjects:
Irritable bowel syndrome
Genetic overlap
Psychiatric disorder
Gut-brain axis
Online Access:https://doi.org/10.1186/s13073-023-01212-4

Internet

https://doi.org/10.1186/s13073-023-01212-4

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