Dual targeting of the androgen receptor and PI3K/AKT/mTOR pathways in prostate cancer models improves antitumor efficacy and promotes cell apoptosis

Dual targeting of the androgen receptor and PI3K/AKT/mTOR pathways in prostate cancer models improves antitumor efficacy and promotes cell apoptosis

Prostate cancer is a frequent malignancy in older men and has a very high 5‐year survival rate if diagnosed early. The prognosis is much less promising if the tumor has already spread outside the prostate gland. Targeted treatments mainly aim at blocking androgen receptor (AR) signaling and initiall...

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Bibliographic Details
Main Authors: Tatsuo Sugawara, Ekaterina Nevedomskaya, Simon Heller, Annika Böhme, Ralf Lesche, Oliver vonAhsen, Sylvia Grünewald, Holly M. Nguyen, Eva Corey, Simon J. Baumgart, Victoria Georgi, Vera Pütter, Amaury Fernández‐Montalván, James D. Vasta, Matthew B. Robers, Oliver Politz, Dominik Mumberg, Bernard Haendler
Format: Article
Language:English
Published: Wiley 2024-03-01
Series:Molecular Oncology
Subjects:
androgen receptor
PI3 kinase
Prostate
Online Access:https://doi.org/10.1002/1878-0261.13577

Internet

https://doi.org/10.1002/1878-0261.13577

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