SARS-CoV-2 spike glycosylation affects function and neutralization sensitivity

SARS-CoV-2 spike glycosylation affects function and neutralization sensitivity

ABSTRACTThe glycosylation of viral envelope proteins can play important roles in virus biology and immune evasion. The spike (S) glycoprotein of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) includes 22 N-linked glycosylation sequons and 17 O-linked glycosites. We investigated the eff...

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Bibliographic Details
Main Authors: Fengwen Zhang, Fabian Schmidt, Frauke Muecksch, Zijun Wang, Anna Gazumyan, Michel C. Nussenzweig, Christian Gaebler, Marina Caskey, Theodora Hatziioannou, Paul D. Bieniasz
Format: Article
Language:English
Published: American Society for Microbiology 2024-02-01
Series:mBio
Subjects:
SARS-CoV-2
antibody function
neutralization
glycosylation
Online Access:https://journals.asm.org/doi/10.1128/mbio.01672-23

Internet

https://journals.asm.org/doi/10.1128/mbio.01672-23

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