First-in-human study to investigate the safety and pharmacokinetics of salvianolic acid A and pharmacokinetic simulation using a physiologically based pharmacokinetic model

First-in-human study to investigate the safety and pharmacokinetics of salvianolic acid A and pharmacokinetic simulation using a physiologically based pharmacokinetic model

Salvianolic acid A (SAA) is a water-soluble phenolic acid component from Salvia miltiorrhiza Bunge currently under development for myocardial protection treatment for coronary heart disease (CHD). We investigated the safety, tolerability, and pharmacokinetics of single and multiple ascending doses o...

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Bibliographic Details
Main Authors: Jinliang Chen, Zourong Ruan, Honggang Lou, Dandan Yang, Rong Shao, Yichao Xu, Xinhua Hu, Bo Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Pharmacology
Subjects:
salvianolic acid A
pharmacokinetics
safety
membrane transporter
physiologically based pharmacokinetic model
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.907208/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.907208/full

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