Protein Expression Knockdown in Cancer Cells Induced by a Gemini Cationic Lipid Nanovector with Histidine-Based Polar Heads

Protein Expression Knockdown in Cancer Cells Induced by a Gemini Cationic Lipid Nanovector with Histidine-Based Polar Heads

A histidine-based gemini cationic lipid, which had already demonstrated its efficiency as a plasmid DNA (pDNA) nanocarrier, has been used in this work to transfect a small interfering RNA (siRNA) into cancer cells. In combination with the helper lipid monoolein glycerol (MOG), the cationic lipid was...

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Bibliographic Details
Main Authors: Natalia Sánchez-Arribas, María Martínez-Negro, Eva M. Villar, Lourdes Pérez, José Osío Barcina, Emilio Aicart, Pablo Taboada, Andrés Guerrero-Martínez, Elena Junquera
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Pharmaceutics
Subjects:
Non-viral gene delivery
gene knockdown efficiency
small interfering RNA
amino acid-based gemini cationic lipids
protein expression
protein corona
Online Access:https://www.mdpi.com/1999-4923/12/9/791

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https://www.mdpi.com/1999-4923/12/9/791

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