Traumatic brain injury induces TDP-43 mislocalization and neurodegenerative effects in tissue distal to the primary injury site in a non-transgenic mouse

Traumatic brain injury induces TDP-43 mislocalization and neurodegenerative effects in tissue distal to the primary injury site in a non-transgenic mouse

Abstract Traumatic brain injury (TBI) initiates tissue and cellular damage to the brain that is immediately followed by secondary injury sequalae with delayed and continual damage. This secondary damage includes pathological processes that may contribute to chronic neurodegeneration and permanent fu...

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Bibliographic Details
Main Authors: George R. Bjorklund, Jennifer Wong, David Brafman, Robert Bowser, Sarah E. Stabenfeldt
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Acta Neuropathologica Communications
Subjects:
Traumatic brain injury
TBI
TDP-43
Neurodegeneration
ALS
Amyotrophic lateral sclerosis
Online Access:https://doi.org/10.1186/s40478-023-01625-7

Internet

https://doi.org/10.1186/s40478-023-01625-7

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