Distinct oncogenic phenotypes in hematopoietic specific deletions of Trp53

Distinct oncogenic phenotypes in hematopoietic specific deletions of Trp53

Abstract Loss of function in the tumor suppressor gene TP53 is the most common alteration seen in human cancer. In mice, P53 deletion in all cells leads predominantly to the development of T-cell lymphomas, followed by B-cell lymphomas, sarcomas and teratomas. In order to dissect the role of P53 in...

Full description

Bibliographic Details
Main Authors: Jayanth Kumar Palanichamy, Tiffany M. Tran, Jennifer K. King, Sol Katzman, Alexander J. Ritter, Gunjan Sharma, Christine Tso, Jorge R. Contreras, Thilini R. Fernando, Jeremy R. Sanford, Dinesh S. Rao
Format: Article
Language:English
Published: Nature Portfolio 2023-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-33949-8

Internet

https://doi.org/10.1038/s41598-023-33949-8

Similar Items