Blocking CCN2 Reduces Established Bone Loss Induced by Prolonged Intense Loading by Increasing Osteoblast Activity in Rats

Blocking CCN2 Reduces Established Bone Loss Induced by Prolonged Intense Loading by Increasing Osteoblast Activity in Rats

ABSTRACT We have an operant model of reaching and grasping in which detrimental bone remodeling is observed rather than beneficial adaptation when rats perform a high‐repetition, high‐force (HRHF) task long term. Here, adult female Sprague–Dawley rats performed an intense HRHF task for 18 weeks, whi...

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Bibliographic Details
Main Authors: Alex G Lambi, Michele Y Harris, Mamta Amin, Patrice G Joiner, Brendan A Hilliard, Soroush Assari, Steven N Popoff, Mary F Barbe
Format: Article
Language:English
Published: Wiley 2023-09-01
Series:JBMR Plus
Subjects:
CCN2
CTGF
MUSCULOSKELETAL DISORDERS
OSTEOPENIA
OVERUSE
PAMREVLUMAB
Online Access:https://doi.org/10.1002/jbm4.10783

Internet

https://doi.org/10.1002/jbm4.10783

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