Sesquiterpene Lactones Modulated DNA Methylation through Inhibition of DNMTs in Ovarian Cancer Cells

Sesquiterpene Lactones Modulated DNA Methylation through Inhibition of DNMTs in Ovarian Cancer Cells

Inappropriate DNA methylation of tumour suppressor genes can affect their expression and function, and as such, DNA methylation has been a promising target for anti-cancer therapy. In gynaecological malignancy, ovarian cancer has the highest associated rate of mortality. This study investigated the...

Full description

Bibliographic Details
Main Authors: Idowu Fadayomi, Suat Sari, Mark Kitchen, Jóhannes Reynisson, Nicholas Forsyth, Wen-Wu Li
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Pharmacological Research - Modern Chinese Medicine
Subjects:
Ovarian cancer
Sesquiterpene lactone
Dehydroleucodine
DNA methylation
DNMT inhibitors
Apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2667142522000355

Internet

http://www.sciencedirect.com/science/article/pii/S2667142522000355

Similar Items