Microparticle RSV Vaccines Presenting the G Protein CX3C Chemokine Motif in the Context of TLR Signaling Induce Protective Th1 Immune Responses and Prevent Pulmonary Eosinophilia Post-Challenge

Microparticle RSV Vaccines Presenting the G Protein CX3C Chemokine Motif in the Context of TLR Signaling Induce Protective Th1 Immune Responses and Prevent Pulmonary Eosinophilia Post-Challenge

Layer-by-layer microparticle (LbL-MP) fabrication was used to produce synthetic vaccines presenting a fusion peptide containing RSV G protein CX3C chemokine motif and a CD8 epitope of the RSV matrix protein 2 (GM2) with or without a covalently linked TLR2 agonist (Pam3.GM2). Immunization of BALB/c m...

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Bibliographic Details
Main Authors: Thomas J. Powell, Andrea Jacobs, Jie Tang, Edwin Cardenas, Naveen Palath, Jennifer Daniels, James G. Boyd, Harrison C. Bergeron, Patricia A. Jorquera, Ralph A. Tripp
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Vaccines
Subjects:
RSV
G protein
vaccine
microparticle
CX3C
eosinophils
Online Access:https://www.mdpi.com/2076-393X/10/12/2078

Internet

https://www.mdpi.com/2076-393X/10/12/2078

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