A systematic enhancer screen using lentivector transgenesis identifies conserved and non-conserved functional elements at the Olig1 and Olig2 locus.

A systematic enhancer screen using lentivector transgenesis identifies conserved and non-conserved functional elements at the Olig1 and Olig2 locus.

Finding sequences that control expression of genes is central to understanding genome function. Previous studies have used evolutionary conservation as an indicator of regulatory potential. Here, we present a method for the unbiased in vivo screen of putative enhancers in large DNA regions, using th...

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Bibliographic Details
Main Authors: Marc Friedli, Isabelle Barde, Mélanie Arcangeli, Sonia Verp, Alexandra Quazzola, Jozsef Zakany, Nathalie Lin-Marq, Daniel Robyr, Catia Attanasio, François Spitz, Denis Duboule, Didier Trono, Stylianos E Antonarakis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3012086?pdf=render

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http://europepmc.org/articles/PMC3012086?pdf=render

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