Natural product (−)‐gossypol inhibits colon cancer cell growth by targeting RNA‐binding protein Musashi‐1

Natural product (−)‐gossypol inhibits colon cancer cell growth by targeting RNA‐binding protein Musashi‐1

Musashi‐1 (MSI1) is an RNA‐binding protein that acts as a translation activator or repressor of target mRNAs. The best‐characterized MSI1 target is Numb mRNA, whose encoded protein negatively regulates Notch signaling. Additional MSI1 targets include the mRNAs for the tumor suppressor protein APC th...

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Bibliographic Details
Main Authors: Lan Lan, Carl Appelman, Amber R. Smith, Jia Yu, Sarah Larsen, Rebecca T. Marquez, Hao Liu, Xiaoqing Wu, Philip Gao, Anuradha Roy, Asokan Anbanandam, Ragul Gowthaman, John Karanicolas, Roberto N. De Guzman, Steven Rogers, Jeffrey Aubé, Min Ji, Robert S. Cohen, Kristi L. Neufeld, Liang Xu
Format: Article
Language:English
Published: Wiley 2015-08-01
Series:Molecular Oncology
Subjects:
RNA binding protein
Wnt
Notch
Musashi-1
Colon cancer
Online Access:https://doi.org/10.1016/j.molonc.2015.03.014

Internet

https://doi.org/10.1016/j.molonc.2015.03.014

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