Imaging the TGFβ type I receptor in pulmonary arterial hypertension

Imaging the TGFβ type I receptor in pulmonary arterial hypertension

Abstract Transforming growth factor β (TGFβ) activity is perturbed in remodelled pulmonary vasculature of patients with pulmonary arterial hypertension (PAH), cancer, vascular diseases and developmental disorders. Inhibition of TGFβ, which signals via activin receptor-like kinase 5 (ALK5), prevents...

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Bibliographic Details
Main Authors: Lonneke Rotteveel, Alex J. Poot, Esther J. M. Kooijman, Robert C. Schuit, Ingrid Schalij, Xiaoqing Sun, Kondababu Kurakula, Chris Happé, Wissam Beaino, Peter ten Dijke, Adriaan A. Lammertsma, Harm Jan Bogaard, Albert D. Windhorst
Format: Article
Language:English
Published: SpringerOpen 2023-03-01
Series:EJNMMI Research
Subjects:
TGFβ type I receptor
ALK5
Positron emission tomography
Pulmonary arterial hypertension
SuHx
MCT
Online Access:https://doi.org/10.1186/s13550-023-00966-7

Internet

https://doi.org/10.1186/s13550-023-00966-7

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