Insights into the inhibition of type I-F CRISPR-Cas system by a multifunctional anti-CRISPR protein AcrIF24

Insights into the inhibition of type I-F CRISPR-Cas system by a multifunctional anti-CRISPR protein AcrIF24

Phages use anti-CRISPR proteins (Acrs) to counteract the bacterial CRISPR-Cas systems. Here, the authors characterize AcrIF24, which functions as an Aca (Acr-associated) to repress and regulate its own transcription, dimerizes the Csy complex, blocks the hybridization of target DNA, and tethers non-...

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Bibliographic Details
Main Authors: Lingguang Yang, Laixing Zhang, Peipei Yin, Hao Ding, Yu Xiao, Jianwei Zeng, Wenhe Wang, Huan Zhou, Qisheng Wang, Yi Zhang, Zeliang Chen, Maojun Yang, Yue Feng
Format: Article
Language:English
Published: Nature Portfolio 2022-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-29581-1

Internet

https://doi.org/10.1038/s41467-022-29581-1

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