Ultrasound-targeted semaglutide-loaded PEG-nanoliposomes microbubble destruction protects diabetic cardiomyopathy by activating PI3K/Akt/Nrf2 signaling pathway

Ultrasound-targeted semaglutide-loaded PEG-nanoliposomes microbubble destruction protects diabetic cardiomyopathy by activating PI3K/Akt/Nrf2 signaling pathway

Objective: To investigate the ameliorative effect of Semaglutide-loaded PEG-nanoliposomes (Sem-PEG-lips) combined with ultrasound-targeted microbubble destruction (UTMD) on streptozotocin (STZ)-induced diabetic cardiomyopathy (DCM) in rodents and its potential mechanisms. Methods: Sem-PEG-lips were...

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Bibliographic Details
Main Authors: Jiawei Zhu, Huiyang Wang, Chunyang Yan, Bin Li, Bin Chen
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Heliyon
Subjects:
Semaglutide
PEG
Nanoliposome
UTMD
Diabetic cardiomyopathy
PI3K/Akt/Nrf2 signaling pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023070810

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http://www.sciencedirect.com/science/article/pii/S2405844023070810

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