BAX as the mediator of C-MYC sensitizes acute lymphoblastic leukemia to TLR9 agonists

BAX as the mediator of C-MYC sensitizes acute lymphoblastic leukemia to TLR9 agonists

Key points TLR9 is not only a prognostic biomarker but also a potential target for B-ALL therapy. C-MYC-mediated BAX activation leads to CpG 685-induced apoptosis in B-ALL.

Bibliographic Details
Main Authors: Ling Bai, Lei Zhou, Wei Han, Jingtao Chen, Xiaoyi Gu, Zheng Hu, Yongguang Yang, Wei Li, Xiaoying Zhang, Chao Niu, Yongchong Chen, Hui Li, Jiuwei Cui
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Journal of Translational Medicine
Subjects:
Toll-like receptor 9
B-cell acute lymphoblastic leukemia
CpG oligodeoxynucleotide
Apoptosis
BAX
Online Access:https://doi.org/10.1186/s12967-023-03969-z

Internet

https://doi.org/10.1186/s12967-023-03969-z

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