Computational Approaches to the Rational Design of Tubulin-Targeting Agents

Computational Approaches to the Rational Design of Tubulin-Targeting Agents

Microtubules are highly dynamic polymers of α,β-tubulin dimers which play an essential role in numerous cellular processes such as cell proliferation and intracellular transport, making them an attractive target for cancer and neurodegeneration research. To date, a large number of known tubulin bind...

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Bibliographic Details
Main Authors: Helena Pérez-Peña, Anne-Catherine Abel, Maxim Shevelev, Andrea E. Prota, Stefano Pieraccini, Dragos Horvath
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Biomolecules
Subjects:
computer-aided drug design
microtubules
microtubule targeting agents
virtual screening
molecular docking
molecular dynamics simulations
Online Access:https://www.mdpi.com/2218-273X/13/2/285

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https://www.mdpi.com/2218-273X/13/2/285

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