Mislocalization, aggregation formation and defect in proteolysis in ALS

Mislocalization, aggregation formation and defect in proteolysis in ALS

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by motoneuron degeneration. The features observed in ALS are the mislocalization and aggregation of proteins in the affected motoneurons. The mutants of Cu/Zn superoxide dismutase (SOD1) or TAR DNA binding protein (TDP-...

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Bibliographic Details
Main Authors: Atsushi Tsubota, Hidenori Ichijo, Kengo Homma
Format: Article
Language:English
Published: AIMS Press 2016-05-01
Series:AIMS Molecular Science
Subjects:
Amyotrophic lateral sclerosis (ALS)
Cu/Zn superoxide dismutase (SOD1)
TAR DNA binding protein (TDP-43)
Fused in sarcoma (FUS)
Chromosome 9 open reading frame 72 (<em>C9ORF72</em>)
mislocalization
aggregation
proteolysis
endoplasmic reticulum (ER)
Online Access:http://www.aimspress.com/Molecular/article/797/fulltext.html

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