Targeting Post-Translational Modifications of the p73 Protein: A Promising Therapeutic Strategy for Tumors

Targeting Post-Translational Modifications of the p73 Protein: A Promising Therapeutic Strategy for Tumors

The tumor suppressor p73 is a member of the p53 family and is expressed as different isoforms with opposing properties. The TAp73 isoforms act as tumor suppressors and have pro-apoptotic effects, whereas the ΔNp73 isoforms lack the N-terminus transactivation domain and behave as oncogenes. The TAp73...

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Bibliographic Details
Main Authors: Ziad Omran, Mahmood H. Dalhat, Omeima Abdullah, Mohammed Kaleem, Salman Hosawi, Fahd A Al-Abbasi, Wei Wu, Hani Choudhry, Mahmoud Alhosin
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Cancers
Subjects:
p73
post-translational modification
ubiquitin
phosphorylation
acetylation
cancer therapy
Online Access:https://www.mdpi.com/2072-6694/13/8/1916

Internet

https://www.mdpi.com/2072-6694/13/8/1916

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